Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 25-32 , March 2009

Expression of the signal transducer and activator of transcription factor 3 and Janus kinase 3 in colorectal carcinomas, colonic adenomas and ulcerative colitis

  • Mohamed M. Shareef

      Affiliations

    • Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt
  • ,
  • Maha M. Shamloula

      Affiliations

    • Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt
  • ,
  • Asem A. Elfert

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
    • Corresponding Author InformationCorresponding author. Tel.: +20 (40) 3333 931; fax: +20 (40) 340 7734.
  • ,
  • Mohamed El-sawaf

      Affiliations

    • Department of Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt
  • ,
  • Hanan H. Soliman

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt

References 

  1. Maurer GD, Leupold JH, Schewe DM, et al. Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer. Clin Cancer Res. 2007;13(4):1123–1132
  2. Caron RW, Yacoub A, Li M, et al. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1 and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther. 2005;4(2):257–270
  3. Darnell JE. STATs and gene regulation. Science. 1997;277(5332):1630–1635
  4. Chakraborty A, Tweardy DJ. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol. 1998;64(5):675–680
  5. Zhong Z, Wen Z, Darnell JE. STAT3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264(5155):95–98
  6. Ma XT, Wang S, Ye YJ, et al. Constitutive activation of STAT3 signaling pathway in human colorectal carcinoma. World J Gastroenterol. 2004;10(11):1569–1573
  7. Lassmann S, Schuster I, Walch A, et al. STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. J Clin Pathol. 2007;60(2):173–179
  8. Xiong H, Zhang ZG, Tian XQ, et al. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest and reduces tumor cell invasion in colorectal cancer cells. Neoplasia. 2008;10(3):287–297
  9. Lacronique V, Boureux A, Valle VD, et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997;278(5341):1309–1312
  10. Zhang F, Li C, Halfter H, et al. Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene. 2003;22(6):894–905
  11. Alvarez JV, Greulich H, Sellers WR, et al. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res. 2006;66(6):3162–3168
  12. Zamo A, Chiarle R, Piva R, et al. Anaplastic lymphoma kinase (ALK) activates STAT3 and protects hematopoietic cells from cell death. Oncogene. 2002;21(7):1038–1047
  13. Yamashita H, Iwase H, Toyama T, et al. Naturally occurring dominant-negative STAT5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. Oncogene. 2003;22(11):1638–1652
  14. Mora LB, Buettner R, Seigne J, et al. Constitutive activation of STAT3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002;62(22):6659–6666
  15. Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002;8(4):945–954
  16. Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut. 2000;47(2):251–255
  17. Hamilton SR, Aatlonen LA. Pathology and genetics of tumors of the digestive system. Lyon, France: IARC Press; 2000;
  18. Dukes CE. The surgical pathology of rectal cancer. J Clin Pathol. 1949;2(2):95–98
  19. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. 6th ed.. New York, NY, USA: Springer; 2002;
  20. Campbell CL, Jiang Z, Savarese DM, et al. Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. Am J Pathol. 2001;158(1):25–32
  21. Bromberg JF, Wrzeszczynska MH, Devgan G, et al. STAT3 as an oncogene. Cell. 1999;98(3):295–303
  22. Bromberg J, Darnell JE. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 2000;19(21):2468–2473
  23. Calo V, Migliavacca M, Bazan V, et al. STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol. 2003;197(2):157–168
  24. Heinrich PC, Behrmann I, Haan S, et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374(Pt. 1):1–20
  25. Matsui T, Kinoshita T, Hirano T, et al. STAT3 down-regulates the expression of cyclin D during liver development. J Biol Chem. 2002;277(39):36167–36173
  26. Barre B, Avril S, Coqueret O. Opposite regulation of myc and p21waf1 transcription by STAT3 proteins. J Biol Chem. 2003;278(5):2990–2996
  27. Kusaba T, Nakayama T, Yamazumi K, et al. Activation of STAT3 is a marker of poor prognosis in human colorectal cancer. Oncol Rep. 2006;15(6):1445–1451
  28. Lin Q, Lai R, Chirieac LR, et al. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol. 2005;167(4):969–980
  29. Masuda M, Suzui M, Yasumatu R, et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res. 2002;62(12):3351–3355
  30. Tsareva SA, Moriggl R, Corvinus FM, et al. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia. 2007;9(4):279–291
  31. Dowlati A, Nethery D, Kern JA. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004;3(4):459–463

PII: S1687-1979(09)00002-1

doi: 10.1016/j.ajg.2009.03.006

Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 25-32 , March 2009