Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 4-9, March 2009

Hepatitis C intervention research – Where are we now and where should we be heading?

  • Tahany Awad

      Affiliations

    • Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 35 45 71 75; fax: +45 35 45 71 01.
    • ,
  • Kristian Thorlund

      Affiliations

    • Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    • ,
  • Mahasen Mabrouk

      Affiliations

    • Department of Endemic Medicine, Cairo University, Cairo, Egypt
    • ,
  • Christian Gluud

      Affiliations

    • Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark

Abstract 

In this paper we outline some of the major pending research questions that lie ahead in hepatitis C intervention research. We argue why these should be answered with randomised clinical trials and we stress how Egypt and other Arab countries can play an important role in this context. We delineate a number of design issues relevant to recent and future hepatitis C randomised clinical trials and provide insights on how and why randomised clinical trial designed in a pragmatic and evidence-based framework will efficiently answer pending research questions.

Keywords: Hepatitis C, Transmission, Prevalence, Epidemiology

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PII: S1687-1979(09)00003-3

doi:10.1016/j.ajg.2009.03.005

Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 4-9, March 2009

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