Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 14-20 , March 2009

Non-invasive fibrosis seromarkers as a predictor of liver fibrosis in chronic hepatitis C and/or non-alcoholic steatohepatitis

  • Laila Ahmed

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Hosny Salama

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    • Department of Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • Department of Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Rasha Ahmed

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    • Corresponding Author InformationCorresponding author. Tel.: +20 103498230/2 37776716; fax: +20 227947807.
    • ,
  • Sherif Hamdy

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Wafaa Al-Akel

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Sanaa Abdel Shafi

      Affiliations

    • Department of Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Abeer Mahgoub

      Affiliations

    • Department of Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Amal Hareedy

      Affiliations

    • Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
    • ,
  • Wael Fathy

      Affiliations

    • Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

References 

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  5. Halfon P, Bourliere M, Panaranda G. Noninvasive methods for predicting liver fibrosis in patients with chronic hepatitis C: alternatives to liver biopsy. Presse Med. 2007;36(3 Pt 2):457–466
  6. Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38:518–526
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  8. Loko MA, Castera L, Dabis F, Le Bail B, Winnock M, Coureau G, et al. Validation and comparison of simple non invasive indexes for predicting liver fibrosis in HIV–HCV-coinfected patients: ANRS CO3 Aquitaine cohort. Am J Gastroenterol. 2008;103(8):1973–1980
  9. Carvalho-Filho RJ, Schiavon LL, Narciso-Schiavon JL, Sampaio JP, Lanzoni VP, Ferraz ML, et al. Optimized cutoffs improve performance of the aspartate aminotransferase to platelet ratio index for predicting significant liver fibrosis in human immunodeficiency virus/hepatitis C virus co-infection. Liver Int. 2008;28(4):486–493
  10. Aiglová K, Ehrmann J, Ehrmann J. Non-invasive detection of liver fibrosis in patients with chronic hepatitis C. Cas Lek Cesk. 2007;146(6):542–545
  11. Nermine Ehsan, Badr Mohamed Tawfik, Raouf Ahmed Abas, Badra Gamal. Correlation between liver biopsy findings and different serum biochemical tests in staging fibrosis in Egyptian patients with chronic hepatitis C virus infection. Arab J Gastroenterol. 2008;9(1):7–12
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  13. Imbert-Bismut F, Ratziu V, Pieroni L, et al. Biochemical markers of liver fibrosis in patients with HCV infection: a prospective study. Lancet. 2001;357:1069–1075
  14. Potdar PD, Andrews KL, Netteshi P, et al. Expression and regulation of GGT related enzyme. Am J Physiol. 1997;273(5):1082–1089
  15. Rossi E, Adams L, Prins A. Validation of FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients. Clin Chem. 2003;49:450–454
  16. Sakai K, Lowman HB, Clemmons DR. Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture. J Biol Chem. 2002;277:13620–13627
  17. Esraa Abdel Salam Bishr, Hala Abbass Abdel Aziz, Gamal Esmat, Randa Sabri. Biochemical markers of liver fibrosis in HCV patients. MSc Thesis. Chemical Pathology Dept., Cairo University; 2004.
  18. Abdelmotaleb M, El-Dafrawy M, Zakaria M. Study of some non-invasive markers of fibrosis with histopathological correlation with chronic liver diseases (Abstract). Liver Int. 2006;26(1):37
  19. Ratziu V, Massard J, Charlotte F. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2006;6:6
  20. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR and DOSVIRC groups. Lancet. 1997;349:825–832
  21. Ahmed L, Fouad R, Zayed N, Hunter SS, Salama A, Hamdy S, et al. Diagnostic accuracy of simple non invasive tests for prediction and staging of fibrosis in patients with chronic hepatitis C. Kasr El-Aini Med J. 2005;11:169–179
  22. Oren R, Horsburgh CR, Timothy C, et al. The performance of APRI for the diagnosis of significant hepatic fibrosis is improved by simple modification. AASLD, November 11, 2005, San Francisco.

PII: S1687-1979(09)00004-5

doi: 10.1016/j.ajg.2009.03.007

Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 14-20 , March 2009

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