Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 10-13 , March 2009

Serum HCV-RNA levels in patients with chronic hepatitis C: Correlation with histological features

  • Luay E. Al-Khurri

      Affiliations

    • Pathology Department, College of Medicine, Baghdad University, Baghdad, Iraq
    • ,
  • Khitam R. Al-Khafaji

      Affiliations

    • Pathology Department, College of Medicine, Baghdad University, Baghdad, Iraq
    • ,
  • Suhair A. Al-Salihi

      Affiliations

    • Laboratory Department, Gastroenterology and Hepatology Teaching Hospital, Medical City, Baghdad, Iraq
    • Corresponding Author InformationCorresponding author. Tel.: +9641 4141052; mobile: +9647901357290/+963956425914; fax: +9641 4154642.
    • ,
  • Safa A.A. Alwaysi

      Affiliations

    • Laboratory Department, Gastroenterology and Hepatology Teaching Hospital, Medical City, Baghdad, Iraq
    • ,
  • Raghad J. Al-Akayshi

      Affiliations

    • Medical Department, Gastroenterology and Hepatology Teaching Hospital, Medical City, Baghdad, Iraq

References 

  1. Global surveillance and control of hepatitis C. Report of a WHO consultation organized in collaboration with the viral hepatitis prevention board, Antwerp, Belgium. J Viral Hepat 1999;6(1):35–47.
  2. Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244(4902):359–362
  3. Seeff LB, Miller RN, Rabkin CS, et al. 45-year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med. 2000;132(2):105–111
  4. Alberti A, Chemello L, Benvegnu L. Natural history of hepatitis C. J Hepatol. 1999;31(Suppl. 1):17–24
  5. Shindo M, Di Bisceglie AM, Biswas R, et al. Hepatitis C virus replication during acute infection in the chimpanzee. J Infect Dis. 1992;166(2):424–427
  6. Kato N, Yokosuka O, Hosoda K, et al. Quantification of hepatitis C virus by competitive reverse transcription-polymerase chain reaction: increase of the virus in advanced liver disease. Hepatology. 1993;18(1):16–20
  7. Yuki N, Hayashi N, Kamada T. HCV viraemia and liver injury in symptom-free blood donors. Lancet. 1993;342(8868):444
  8. Hu KQ, Yu CH, Vierling JM. Direct detection of circulating hepatitis C virus RNA using probes from the 5′ untranslated region. J Clin Invest. 1992;89(6):2040–2045
  9. Di Bisceglie AM, Hoofnagle JH, Krawczynski K. Changes in hepatitis C virus antigen in liver with antiviral therapy. Gastroenterology. 1993;105(3):858–862
  10. Tsukiyama Kohara K, Iizuka N, Kohara M, et al. Internal ribosome entry site within hepatitis C virus RNA. J Virol. 1992;66(3):1476–1483
  11. Wang C, Le SY, Ali N, et al. An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5′ noncoding region. RNA. 1995;1(5):526–537
  12. Lau JY, Davis GL, Kniffen J, et al. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet. 1993;341(8859):1501–1504
  13. Naito M, Hayashi N, Hagiwara H, et al. Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels. Hepatology. 1994;19(4):871–875
  14. Gretch D, Corey L, Wilson J, et al. Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease. J Infect Dis. 1994;169(6):1219–1225
  15. Gretch DR, dela Rosa C, Carithers RL, et al. Assessment of hepatitis C viremia using molecular amplification technologies: correlations and clinical implications. Ann Intern Med. 1995;123(5):321–329
  16. Coelho Little E, Jeffers LJ, Bartholomew M, et al. Correlation of HCV-RNA levels in serum and liver of patients with chronic hepatitis C. J Hepatol. 1995;22(4):508
  17. Francesconi R, Manzin A, Giosta F, et al. Quantification of liver HCV-RNA: relation to number of HCV infected hepatocytes, HCV genotypes, HCV viremia and response to IFN treatment. Ital J Gastroenterol. 1995;27:213–214
  18. Yathsuhashi H, Inoue O, Koga M, et al. Correlation between serum and liver tissue HCV-RNA levels in patients with chronic hepatitis C. Int Hepatol Commun. 1995;3:35–40
  19. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22(6):696–699
  20. Rosai J. Rosai and Ackerman’s surgical pathology. 9th ed.. Mosby; 2004;
  21. De Moliner L, Pontisso P, De Salvo GL, et al. Serum and liver HCV RNA levels in patients with chronic hepatitis C: correlation with clinical and histological features. Gut. 1998;42(6):856–860
  22. Lagging LM, Garcia CE, Westin J, et al. Comparison of serum hepatitis C virus RNA and core antigen concentrations and determination of whether levels are associated with liver histology or affected by specimen storage time. J Clin Microbiol. 2002;40(11):4224–4229
  23. Saleem N, Mubarik A, Qureshi AH, et al. Is there a correlation between degree of viremia and liver histology in chronic hepatitis C?. J Pak Med Assoc. 2004;54(9):476–479
  24. Fanning L, Kenny E, Sheehan M, et al. Viral load and clinicopathological features of chronic hepatitis C (1b) in a homogeneous patient population. Hepatology. 1999;29(3):904–907
  25. Pal S, Shuhart MC, Thomassen L, et al. Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo. J Virol. 2006;80(5):2280–2290
  26. Simmonds P. Variability of hepatitis C virus. Hepatology. 1995;21(2):570–583
  27. Kobayashi M, Tanaka E, Sodeyama T, et al. The natural course of chronic hepatitis C: a comparison between patients with genotypes 1 and 2 hepatitis C viruses. Hepatology. 1996;23(4):695–699
  28. Prati D, Capelli C, Zanella A, et al. Influence of different hepatitis C virus genotypes on the course of asymptomatic hepatitis C virus infection. Gastroenterology. 1996;110(1):178–183
  29. Yamada M, Kakumu S, Yoshioka K, et al. Hepatitis C virus genotypes are not responsible for development of serious liver disease. Dig Dis Sci. 1994;39(2):234–239
  30. Brillanti S, Foli M, Gaiani S, et al. Persistent hepatitis C viraemia without liver disease. Lancet. 1993;341(8843):464–465
  31. Krawczynski K, Beach MJ, Bradley DW, et al. Hepatitis C virus antigen in hepatocytes: immunomorphologic detection and identification. Gastroenterology. 1992;103(2):622–629
  32. Thomas HC, Jacyna M, Waters J, et al. Virus-host interaction in chronic hepatitis B virus infection. Semin Liver Dis. 1988;8(4):342–349
  33. Barnaba V, Balsano F. Immunologic and molecular basis of viral persistence. The hepatitis B virus model. J Hepatol. 1992;14(2–3):391–400
  34. Koziel MJ, Dudley D, Wong JT, et al. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol. 1992;149(10):3339–3344
  35. Ferrari C, Valli A, Galati L, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology. 1994;19(2):286–295
  36. Cerny A, McHutchison JG, Pasquinelli C, et al. Hepatitis C virus specific cytotoxic T cell response: identification of multiple HLA-2 restricted epitopes. J Clin Invest. 1995;95:521–530

PII: S1687-1979(09)00006-9

doi: 10.1016/j.ajg.2009.03.003

Arab Journal of Gastroenterology
Volume 10, Issue 1 , Pages 10-13 , March 2009

Article Tools

* Image Usage & Resolution