Arab Journal of Gastroenterology
Volume 10, Issue 3 , Pages 102-105 , September 2009

Effect of pentoxifylline on serum hyaluronic acid in patients with non-alcoholic fatty liver disease

  • Mona A. Amin

      Affiliations

    • Internal Medicine Department, Faculty of Medicine, Cairo University, Egypt
    • Corresponding Author InformationCorresponding author. Address: Al-Maadi – Al-Laselky in front of Dar Resala Villa Dr. Magdy 22D/5 Cairo, Egypt. Mobile: +20 101661910.
    • ,
  • Dina Sabry

      Affiliations

    • Biochemistry Department, Cairo University, Egypt
    • ,
  • Mohamed Kassem

      Affiliations

    • Pharmacy Department, Cairo University, Egypt
    • ,
  • Ahmed Amin

      Affiliations

    • Pharmacy Department, Cairo University, Egypt

Received 13 April 2009 ,Accepted 8 September 2009.

References 

  1. Sanyal AJ, Campbell Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 2001;120(5):1183–1192
  2. Rockey DC, Boyles JK, Gabbiani G, et al. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol. 1992;24(2):193–203
  3. Preaux AM, Mallat A, Rosenbaum J, et al. Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells. Hepatology. 1997;26(2):315–322
  4. Svegliati Baroni G, Di Sario A, Casini A, et al. The Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat hepatic stellate cells. J Hepatol. 1999;30(5):868–875
  5. Day CP, James OF. Steatohepatitis: a tale of two “hits”?. Gastroenterology. 1998;114(4):842–845
  6. Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis. 2001;21(1):27–41
  7. Satapathy SK, Garg S, Chauhan R, et al. Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2004;99(10):1946–1952
  8. Klein C, Gerken G. Invasive versus nicht-invasive verlaufskontrolle – scores als histologieersatz bei chronischer hepatitis? [Evaluation of non-invasive scores in the follow-up of chronic hepatitis]. Schweiz Rundsch Med Prax. 2005;94(16):645–647
  9. Kaneda H, Hashimoto E, Yatsuji S, et al. Hyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2006;21(9):1459–1465
  10. Khan JA, Khan FA, Dilawar M, et al. Serum hyaluronic acid as a marker of hepatic fibrosis. J Coll Physicians Surg Pak. 2007;17(6):323–326
  11. Falck Ytter Y, Younossi ZM, Marchesini G, et al. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis. 2001;21(1):17–26
  12. Adams LA, Zein CO, Angulo P, et al. A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol. 2004;99(12):2365–2368
  13. Lee YM, Sutedja DS, Wai CT, et al. A randomized controlled pilot study of pentoxifylline in patients with non-alcoholic steatohepatitis (NASH). Hepatol Int. 2008;2(2):196–201
  14. Satapathy SK, Sakhuja P, Malhotra V, et al. Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2007;22(5):634–638

PII: S1687-1979(09)00261-5

doi: 10.1016/j.ajg.2009.09.001

Arab Journal of Gastroenterology
Volume 10, Issue 3 , Pages 102-105 , September 2009

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