Arab Journal of Gastroenterology
Volume 10, Issue 4 , Pages 129-134 , December 2009

Prediction of oesophageal varices in patients with compensated cirrhosis: A novel scoring system

Received 8 May 2009 ,Accepted 7 October 2009.

References 

  1. De Franchis R, Primignani M. Natural history of portal hypertension in patients with cirrhosis. Clin Liver Dis. 2001;5(3):645–663
  2. Garceau AJ, Chalmers TC. The natural history of cirrhosis. I. Survival with esophageal varices. N Engl J Med. 1963;268:469–473
  3. Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology. 1981;80(4):800–809
  4. Rigo GP, Merighi A, Chahin NJ, et al. A prospective study of the ability of three endoscopic classifications to predict hemorrhage from esophageal varices. Gastrointest Endosc. 1992;38(4):425–429
  5. Jensen DM. Endoscopic screening for varices in cirrhosis: findings, implications and outcomes. Gastroenterology. 2002;122(6):1620–1630
  6. Grace ND, Groszmann RJ, Garcia Tsao G, et al. Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology. 1998;28(3):868–880
  7. D’Amico G, Garcia Tsao G, Calès P, et al. Diagnosis of portal hypertension: how and when. In: De Franchis R, editor. Portal hypertension III. Proceedings of the third baveno international consensus workshop on definitions, methodology and therapeutic strategies. Oxford, UK: Blackwell Science; 2000. p. 36–64.
  8. Gorka W, Al Mulla A, Al Sebayel M, et al. Qualitative hepatic venous Doppler sonography versus portal flowmetry in predicting the severity of esophageal varices in hepatitis C cirrhosis. AJR Am J Roentgenol. 1997;169(2):511–515
  9. Chalasani N, Imperiale TF, Ismail A, et al. Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol. 1999;94(11):3285–3291
  10. Zaman A, Hapke R, Flora K, et al. Factors predicting the presence of esophageal or gastric varices in patients with advanced liver disease. Am J Gastroenterol. 1999;94(11):3292–3296
  11. Pilette C, Oberti F, Aube C, et al. Non-invasive diagnosis of esophageal varices in chronic liver diseases. J Hepatol. 1999;31(5):867–873
  12. Ng FH, Wong SY, Loo CK, et al. Prediction of oesophagogastric varices in patients with liver cirrhosis. J Gastroenterol Hepatol. 1999;14(8):785–790
  13. Schepis F, Camma C, Niceforo D, et al. Which patients with cirrhosis should undergo endoscopic screening for esophageal varices detection?. Hepatology. 2001;33(2):333–338
  14. Zaman A, Becker T, Lapidus J, et al. Risk factors for the presence of varices in cirrhotic patients without a history of variceal hemorrhage. Arch Intern Med. 2001;161(21):2564–2570
  15. Madhotra R, Mulcahy HE, Willner I, et al. Prediction of esophageal varices in patients with cirrhosis. J Clin Gastroenterol. 2002;34(1):81–85
  16. Amarapurkar DN, Parikh SS, Shankaran K, et al. Correlation between splenomegaly and oesophageal varices in patients with liver cirrhosis. Endoscopy. 1994;26(6):563
  17. Zeijen RNM, Caenepeel P, Stockbrügger RWea. Prediction of esophageal varices in liver disease: preliminary results. Gastroenterol. 1994;106:A1013
  18. Lavergne J, Molina E, Reddy KR, et al. Ascites predicts the presence of high grade varices by screening endoscopy. Gastrointest Endoscop. 1997;45:A649
  19. Garcia Tsao G, Escorsell A, Zakko M, et al. Predicting the presence of significant portal hypertension and varices in compensated cirrhotic patients. Hepatology. 1997;26:A360
  20. Freeman JG, Darlow S, Cole AT. Platelet count as a predictor for the presence of oesophageal varices in alcoholic cirrhotic patients. Gastroenterology. 1999;116:A1211
  21. Riggio O, Angeloni S, Nicolini G, et al. Endoscopic screening for esophageal varices in cirrhotic patients. Hepatology. 2002;35(2):501–502
  22. Giannini EG, Botta F, Borro P, et al. Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: a validation study based on follow-up. Dig Liver Dis. 2005;37(10):779–785
  23. Lee YT, Chan FK, Ching JY, et al. Diagnosis of gastroesophageal varices and portal collateral venous abnormalities by endosonography in cirrhotic patients. Endoscopy. 2002;34(5):391–398
  24. Chiu KC, Sheu BS, Chuang CH. Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. Dig Dis Sci. 2005;50(6):1170–1174
  25. Jalan R, Hayes PC. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. British society of gastroenterology. Gut. 2000;46(Suppl. 3–4):III1–III15
  26. Cales P, Desmorat H, Vinel JP, et al. Incidence of large oesophageal varices in patients with cirrhosis: application to prophylaxis of first bleeding. Gut. 1990;31(11):1298–1302
  27. Christensen E, Fauerholdt L, Schlichting P, et al. Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone. Gastroenterology. 1981;81(5):944–952
  28. Conn HO. Quantifying the severity of hepatic encephalopathy. In:  Conn HO,  Bircher J editor. Hepatic encephalopathy: syndromes and therapies. Bloomington: Medi-Ed Press; 1994;p. 13–26
  29. Thomopoulos KC, Labropoulou Karatza C, Mimidis KP, et al. Non-invasive predictors of the presence of large oesophageal varices in patients with cirrhosis. Dig Liver Dis. 2003;35(7):473–478
  30. Loftus WK, Chow LT, Metreweli C. Sonographic measurement of splenic length: correlation with measurement at autopsy. J Clin Ultrasound. 1999;27(2):71–74
  31. Ghany M. Approach to a patient with chronic liver disease. In: Kasper DL, Braunwald E, Hauser S, et al., editors. Harrison’s principles of internal medicine. 16th ed. McGraw-Hill Professional; 2004. p. 1813.
  32. Cales P, Oberti F, Bernard Chabert B, et al. Evaluation of Baveno recommendations for grading esophageal varices. J Hepatol. 2003;39(4):657–659
  33. Zwiebel WJ. Doppler physics. In: Zwiebel WJ, editor. Introduction to vascular ultrasonography. 4th ed. W.B. Saunders Company; 2000. p. 58–65.
  34. Barakat M, Hassan A, Soliman A, et al. Intrasplenic venous flow patterns demonstrated by Doppler ultrasound in patients with portal hypertension. Br J Radiol. 1998;71(844):384–387
  35. Espanol I, Gallego A, Enriquez J, et al. Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin. Hepatogastroenterology. 2000;47(35):1404–1406
  36. Siringo S, Piscaglia F, Zironi G, et al. Influence of esophageal varices and spontaneous portal-systemic shunts on postprandial splanchnic hemodynamics. Am J Gastroenterol. 2001;96(2):550–556
  37. Nakano R, Iwao T, Oho K, et al. Splanchnic hemodynamic pattern and liver function in patients with cirrhosis and esophageal or gastric varices. Am J Gastroenterol. 1997;92(11):2085–2089
  38. Burton JR, Liangpunsakul S, Lapidus J, et al. Validation of a multivariate model predicting presence and size of varices. J Clin Gastroenterol. 2007;41(6):609–615
  39. Giannini E, Botta F, Borro P, et al. Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis. Gut. 2003;52(8):1200–1205
  40. Thabut D, Ratziu V, Trabut JB, et al. Prediction of oesophageal varices with platelet count/spleen diameter ratio or platelets alone. Gut 2004;53(6):913-4; author reply 914-5.
  41. Agostino C, Mirelia F, Roberta P, et al. Renovascular impedance and esophageal varices in patients with Child-Pugh class A cirrhosis. Radiologe. 2001;219(3):712–715
  42. Runyon BA. Management of adult patients with ascites due to cirrhosis. Hepatology. 2004;39(3):841–856
  43. DiBona GF, Sawin LL. Hepatorenal baroreflex in cirrhotic rats. Am J Physiol Gastrointest Liver Physiol 1995;269(1 32-1):G29–33.
  44. Aydogdu S, Akil I, Akil T, et al. Renal resistive indexes and some renal functions in liver cirrhotic children. Pediatr Int. 2004;46(1):67–71
  45. Pugh RN, Murray Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60(8):646–649

PII: S1687-1979(09)00269-X

doi: 10.1016/j.ajg.2009.10.002

Arab Journal of Gastroenterology
Volume 10, Issue 4 , Pages 129-134 , December 2009