Arab Journal of Gastroenterology
Volume 10, Issue 4 , Pages 146-150 , December 2009

Eradication of Helicobacter pylori decreases the expression of p53 and c-Myc oncogenes

  • Hanan AlSaeid Alshenawy

      Affiliations

    • Department of Pathology, Faculty of Medicine, Tanta University, 25 Ahmed Gado Street, Tanta, Egypt
    • Corresponding Author InformationCorresponding author. Tel.: +20 403296201.
    • ,
  • Amr Mahrous Alshafey

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt

Received 8 July 2009 ,Accepted 8 October 2009.

References 

  1. Kodama M, Murakami K, Okimoto T, et al. Expression of mutant type-p53 products in H. pylori-associated chronic gastritis. World J Gastroenterol. 2007;13(10):1541–1546
  2. Zhu Y, Shu X, Chen J, et al. Effect of Helicobacter pylori eradication on oncogenes and cell proliferation. Eur J Clin Investig. 2008;38(9):628–633
  3. Nardone G, Staibano S, Rocco A, et al. Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis. Gut. 1999;44(6):789–799
  4. Feng CW, Wang LD, Jiao LH, et al. Expression of p53, inducible nitric oxide synthase, vascular endothelial growth factor in gastric precancerous, cancerous lesions correlation with clinical features. BMC Cancer. 2002;2:8
  5. Fox JG, Sheppard BJ, Dangler CA, et al. Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res. 2002;62(3):696–702
  6. Zhang GX, Gu YH, Zhao ZQ, et al. Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases. World J Gastroenterol. 2004;10(12):1759–1762
  7. Kim SS, Meitner P, Konkin TA, et al. Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. Mod Pathol. 2006;19(1):49–58
  8. Lan J, Xiong YY, Lin YX, et al. Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. World J Gastroenterol. 2003;9(1):54–58
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  11. van der Hulst RW, van der Ende A, Dekker FW, et al. Effect of Helicobacter pylori eradication on gastritis in relation to cagA: a prospective 1-year follow-up study. Gastroenterology. 1997;113(1):25–30
  12. Unger Z, Molnar B, Pronai L, et al. Mutant p53 expression and apoptotic activity of Helicobacter pylori positive and negative gastritis in correlation with the presence of intestinal metaplasia. Eur J Gastroenterol Hepatol. 2003;15(4):389–393
  13. Anagnostopoulos GK, Stefanou D, Arkoumani E, et al. Immunohistochemical expression of cell-cycle proteins in gastric precancerous lesions. J Gastroenterol Hepatol. 2008;23(4):626–631
  14. Marinone C, Martinetti A, Mestriner M, et al. P53 evaluation in gastric mucosa of patients with chronic Helicobacter pylori infection. Anticancer Res. 2001;21(2A):1115–1118
  15. Wang J, Chi DS, Kalin GB, et al. Helicobacter pylori infection and oncogene expressions in gastric carcinoma and its precursor lesions. Dig Dis Sci. 2002;47(1):107–113
  16. Zhan N, Xiong YY, Lan J, et al. Relationship between Helicobacter pylori infection and expression of c-myc, Bcl-2, and Bax protein in different gastric mucosa lesions. Ai Zheng. 2003;22(10):1034–1037
  17. Pasztorova I, Chinyama C, Filipe MI. Regression of gastric intestinal metaplasia after eradication of Helicobacter pylori: a prospective study. Gut. 1996;39(S2):A55
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PII: S1687-1979(09)00271-8

doi: 10.1016/j.ajg.2009.10.003

Arab Journal of Gastroenterology
Volume 10, Issue 4 , Pages 146-150 , December 2009

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