Metastatic gastrointestinal stromal tumours of the stomach: A report on two cases and literature review

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the gastrointestinal tract, accounting for approximately 1% of gastric malignancies. We report on two cases of large malignant irresectable stromal tumours of the stomach with presence of concomitant distant metastases, treated palliatively, and followed by adjuvant imatinib therapy. The rarity lies in the presence of distant as well as lymph node metastases. The literature on this topic is reviewed.