Arab Journal of Gastroenterology
Volume 11, Issue 1 , Pages 19-23 , March 2010

Association of MnSOD Ala16Val genotype and activity with hepatocellular carcinoma risk in HCV-infected Egyptian patients

  • Amany Ibrahim

      Affiliations

    • Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    • ,
  • Shymaa Abd El-Azim

      Affiliations

    • Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    • Corresponding Author InformationCorresponding author. Tel.: +20 166324265; fax: +20 553981289.
    • ,
  • Marwa Abd El-Azim

      Affiliations

    • Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Received 26 April 2009 ,Accepted 10 January 2010.

References 

  1. McGlynn KA, Tarone RE, El Serag HB. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev. 2006;15(6):1198–1203
  2. Bosch FX, Ribes J, Cleries R, et al. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9(2):191–211
  3. El Zayadi AR, Badran HM, Barakat EM, et al. Hepatocellular carcinoma in Egypt: a single center study over a decade. World J Gastroenterol. 2005;11(33):5193–5198
  4. Lehman EM, Wilson ML. Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and meta-analysis. Int J Cancer. 2009;124(3):690–697
  5. Ismail AM, Ziada HN, Sheashaa HA, et al. Decline of viral hepatitis prevalence among asymptomatic Egyptian blood donors: a glimmer of hope. Eur J Intern Med. 2009;20(5):490–493
  6. Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004;114(2):147–152
  7. Korenaga M, Wang T, Li Y, et al. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem. 2005;280(45):37481–37488
  8. Thore´n F, Romero A, Lindh M, et al. A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals. J Leukoc Biol. 2004;76(6):1180–1186
  9. Genkinger JM, Platz EA, Hoffman SC, et al. C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival. Mech Ageing Dev. 2006;127(4):371–377
  10. Wallace DC. Mitochondrial diseases in man and mouse. Science. 1999;283(5407):1482–1488
  11. Liu R, Buettner GR, Oberley LW. Oxygen free radicals mediate the induction of manganese superoxide dismutase gene expression by TNF-alpha. Free Radic Biol Med. 2000;28(8):1197–1205
  12. Wispe JR, Clark JC, Burhans MS, et al. Synthesis and processing of the precursor for human mangano-superoxide dismutase. Biochim Biophys Acta. 1989;994(1):30–36
  13. Matsuda Y, Higashiyama S, Kijima Y, et al. Human liver manganese superoxide dismutase. Purification and crystallization, subunit association and sulfhydryl reactivity. Eur J Biochem. 1990;194(3):713–720
  14. Qadri I, Iwahashi M, Capasso JM, et al. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J. 2004;378(Pt 3):919–928
  15. Silva SN, Cabral MN, Bezerra de Castro G, et al. Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17beta1, COMT and MnSOD): possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed. Oncol Rep. 2006;16(4):781–788
  16. Chung man Ho J, Zheng S, Comhair SA, et al. Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Res. 2001;61(23):8578–8585
  17. Izutani R, Asano S, Imano M, et al. Expression of manganese superoxide dismutase in esophageal and gastric cancers. J Gastroenterol. 1998;33(6):816–822
  18. Toh Y, Kuninaka S, Oshiro T, et al. Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. Int J Oncol. 2000;17(1):107–112
  19. Kawaguchi T, Suzuki K, Matsuda Y, et al. Serum-manganese-superoxide dismutase: normal values and increased levels in patients with acute myocardial infarction and several malignant diseases determined by an enzyme-linked immunosorbent assay using a monoclonal antibody. J Immunol Methods. 1990;127(2):249–254
  20. Wan XS, Devalaraja MN, St Clair DK. Molecular structure and organization of the human manganese superoxide dismutase gene. DNA Cell Biol. 1994;13(11):1127–1136
  21. Rosenblum JS, Gilula NB, Lerner RA. On signal sequence polymorphisms and diseases of distribution. Proc Natl Acad Sci USA. 1996;93(9):4471–4473
  22. Sutton A, Khoury H, Prip Buus C, et al. The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics. 2003;13(3):145–157
  23. Sutton A, Imbert A, Igoudjil A, et al. The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability. Pharmacogenet Genom. 2005;15(5):311–319
  24. Buettner GR, Ng CF, Wang M, et al. A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. Free Radic Biol Med. 2006;41(8):1338–1350
  25. http://www.cdc.gov/hepatitis/HCV/HCVfaq.htm.
  26. Nahon P, Sutton A, Pessayre D, et al. Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma and death. Clin Gastroenterol Hepatol. 2005;3(3):292–298
  27. Pugh RN, Murray Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60(8):646–649
  28. Elbeik T, Markowitz N, Nassos P, et al. Simultaneous runs of the Bayer VERSANT HIV-1 version 3.0 and HCV bDNA version 3.0 quantitative assays on the system 340 platform provide reliable quantitation and improved work flow. J Clin Microbiol. 2004;42(7):3120–3127
  29. Degoul F, Sutton A, Mansouri A, et al. Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Gastroenterology. 2001;120(6):1468–1474
  30. Hecker KH, Roux KH. High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR. BioTechniques. 1996;20(3):478–485
  31. http://en.wikipedia.org/wiki/Allele_frequency.
  32. Melhem A, Stern M, Shibolet O, et al. Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial. J Clin Gastroenterol. 2005;39(8):737–742
  33. Sato M, Sasaki M, Hojo H. Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. Arch Biochem Biophys. 1995;316(2):738–744
  34. Abdalla MY, Ahmad IM, Spitz DR, et al. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol. 2005;76(4):489–497
  35. Dasgupta J, Subbaram S, Connor KM, et al. Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006;8(7–8):1295–1305
  36. Waheed A, Grubb JH, Zhou XY, et al. Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA. 2002;99(5):3117–3122
  37. Sutton A, Nahon P, Pessayre D, et al. Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. Cancer Res. 2006;66(5):2844–2852
  38. Jackson JH. Potential molecular mechanisms of oxidant-induced carcinogenesis. Environ Health Perspect. 1994;102(Suppl. 10):155–157
  39. Machida K, Cheng KT, Lai CK, et al. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT 3 activation. J Virol. 2006;80(14):7199–7207
  40. Ezzikouri S, Feydi AEE, Chafik A, et al. Genetic polymorphism in the manganese superoxide dismutase gene is associated with an increased risk for hepatocellular carcinoma in HCV-infected Moroccan patients. Mutat Res. 2008;649(1–2):1–6
  41. Martin RCG, Li Y, Liu Q, et al. Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes. DNA Cell Biol. 2009;28(1):3–7
  42. Van Landeghem GF, Tabatabaie P, Kucinskas V, et al. Ethnic variation in the mitochondrial targeting sequence polymorphism of MnSOD. Hum Hered. 1999;49(4):190–193
  43. Nahon P, Sutton A, Pessayre D, et al. Manganese superoxide dismutase dimorphism and iron overload, hepatocellular carcinoma and death in hepatitis C virus-infected patients. Clin Gastroenterol Hepatol. 2007;5(5):630–635
  44. Clemente C, Elba S, Buongiorno G, et al. Manganese superoxide dismutase activity and incidence of hepatocellular carcinoma in patients with Child–Pugh class A liver cirrhosis: a 7-year follow-up study. Liver Int. 2007;27(6):791–797
  45. Bastaki M, Huen K, Manzanillo P, et al. Genotype–activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. Pharmacogenet Genom. 2006;16(4):279–286

PII: S1687-1979(10)00008-0

doi: 10.1016/j.ajg.2010.01.007

Arab Journal of Gastroenterology
Volume 11, Issue 1 , Pages 19-23 , March 2010

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